Synthesis of N-Z, N′-Formyl α-Amino Acid Derived Gem-Diamines
نویسندگان
چکیده
منابع مشابه
Large-scale synthesis of α-amino acid-N-carboxyanhydrides
Heteroand homopolymers prepared from α-amino acid-N-carboxyanhydrides (NCAs) monomers are widely useful products. The preparation of pure NCA monomers has been extensively studied in the past. Purification methods including repeated crystallizations, extraction, and flash column chromatography have been devised. However, these methods are not easily amendable to large-scale NCA preparations. Th...
متن کاملSynthesis of enantioenriched 1,2-trans-diamines using the borono-Mannich reaction with N-protected α-amino aldehydes.
The three-component Petasis borono-Mannich reaction starting with easily accessible N-protected α-amino aldehydes produces efficiently and diastereoselectively 1,2-trans-diamines with an enantiomeric excess of up to 98%.
متن کاملSynthesis of N-formyl- and N-succinyl-D-neuraminic acid on the specificity of neuraminidase.
The sialic acids are important constituents of numerous glycoproteins, glycolipids, and oligosaccharides. Little is known about their functional signifp cance for the biological effect of these complex substances. In many instances removal of sialic acid is accompanied by a loss of biological activity [I] . So far only N-acetylneuraminic acid (lactaminic acid) and N-glykolylneuraminic acid were...
متن کاملSynthesis of polypeptides by ring-opening polymerization of α-amino acid N-carboxyanhydrides.
This chapter summarizes methods for the synthesis of polypeptides by ring-opening polymerization. Traditional and recently improved methods used to polymerize α-amino acid N-carboxyanhydrides (NCAs) for the synthesis of homopolypeptides are described. Use of these methods and strategies for the preparation of block copolypeptides and side-chain-functionalized polypeptides are also presented, as...
متن کاملOne-pot synthesis of enantiomerically pure N-protected allylic amines from N-protected α-amino esters
An improved protocol for the synthesis of enantiomerically pure allylic amines is reported. N-Protected α-amino esters derived from natural amino acids were submitted to a one-pot tandem reduction-olefination process. The sequential reduction with DIBAL-H at -78 °C and subsequent in situ addition of organophosphorus reagents yielded the corresponding allylic amines without the need to isolate t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Peptide Research and Therapeutics
سال: 2008
ISSN: 1573-3149,1573-3904
DOI: 10.1007/s10989-008-9127-2